The small intestine is one of the intestine parts. It performs many functions, plays a major role in the processes of digesting food and absorbing nutrients. With the development of certain diseases, the work of this department is disrupted - malabsorption syndrome is manifested, which is abbreviated as CMA. What is this term? What are the causes of this syndrome?
In the medical literature, you can find suchterm as "malabsorption". This word is used to denote a violation of absorption of the intestinal mucosa of food components. There is also a term like "maldigestia". This is a violation of the processes of conversion of fats, proteins and carbohydrates into absorbed cleavage products.
Experts combine both of the above terms("Malabsorption" and "maldigestia"), when they speak of malabsorption syndrome. This is how a complex of clinical manifestations emerged due to violations of cavitary, parietal, membrane digestion and transport in the small intestine. Because of the changes that occur in the human body due to the appearance of malabsorption syndrome, metabolic disorders occur. People begin to suffer unpleasant symptoms.
Malabsorption syndrome is observed in manycongenital and hereditary diseases, in which the absorption of substances is impaired, the activity of enzymes is reduced. An example is cystic fibrosis. In this disease, SMA develops because of a decrease in the activity of pancreatic enzymes and a violation of the viscosity of secrets.
Malabsorption syndrome is caused by ailments,caused by infections and parasites, anomalies of the lymphatic and circulatory systems. SMA is also observed with damage to the small intestine and a decrease in the area of absorption (these changes that have occurred in the body cause serious violations of many types of metabolism, physical and mental retardation in development).
Thus, malabsorption is a set of unpleasant symptoms, which can cause a huge number of different causes. They can be combined as follows:
Despite the fact that malabsorption syndrome is inherent indifferent diseases, you can identify the characteristics that are characteristic of him. With AGR, nausea and vomiting occur. At patients the appetite worsens. Symptoms such as flatulence, changes in stools are also observed (most often diarrhea occurs). All these signs are called a dyspeptic syndrome. He is leading in the clinical manifestations of SMA.
The chair deserves special attention. Assessing the characteristics of fecal masses, specialists receive important information that allows them to make the correct diagnosis:
CMA sometimes causes pain. Most often they are caused by intestinal infections and invasions. Pain syndrome can occur after eating dairy products. He combined with a frothy stool with a sour smell, flatulence indicates lactase deficiency. Pain in the abdomen with CMA accompany food allergies, bowel abnormalities, Whipple's disease, ulcerative colitis, Crohn's disease. In the syndrome of malabsorption, the following symptoms are still observed:
Malabsorption in children is accompanied by scarcesyndromes. Physical development is disrupted. This is manifested in a decrease in body weight, development of hypotrophy, growth retardation. The deficit of vitamins is indicated by the state of the skin. The skin becomes dry, begins to peel off. On it there are pigmented spots. The hair becomes thinner and begins to fall out. Nails get a dull shade and exfoliate. When calcium deficiency occurs, cramps, pain in the muscles and bones. The lack of iron, copper and zinc leads to the appearance of skin rashes, the development of iron deficiency anemia, an increase in body temperature.
Malabsorption syndrome unites more than 70various diseases. In this regard, specialists face some difficulties in the preparation of classifications. The most successful is the division into hereditary and acquired syndromes of malabsorption:
There is also a classification based on the severity of malabsorption syndrome:
In 1977, the VIII World Congress of Gastroenterologists was held. On it specialists have identified several types of malabsorption, depending on the causes that cause it:
Lack of bile and secreted by the pancreassubstances, affecting the cavity digestion and causing its violation, - malabsorption intracavitary type. In babies, they arise from cystic fibrosis, congenital hypoplasia of the pancreas. In older children, the appearance of intracavitary malabsorption syndrome provokes such diseases as cirrhosis of the liver, chronic pancreatitis.
The second type of SMA is postcellular malabsorption. This syndrome, which is characterized by the loss of plasma protein through the wall of the intestine. It is observed in abnormalities of the circulatory and lymphatic system. One of the diseases is idiopathic intestinal lymphangiectasia. She has a severe loss of calcium, lipids and proteins in the gastrointestinal tract.
Enterocellular type unites those cases whendisturbed membrane digestion or absorption due to a defect in the enzyme systems of epithelial cells of the intestine. This can be observed in young children because of hereditary diseases associated with the violation:
In children of older age, the enterocellular typeMalabsorption syndrome occurs due to damage and death of intestinal cells due to the influence of infections or parasites, tuberculosis, small bowel tumors, Crohn's disease.
In this type of AGR is more violateddigestion of fats. Their hydrolysis is carried out by lipase of the pancreas, which is activated by bile. With a lack of these substances, a symptom such as steatorrhoea appears. This is a release with a fecal mass of excess fat. The most vividly manifested steatorrhoea in chronic pancreatitis. Less noticeable is this symptom in diseases of the liver and biliary tract.
Among the causes of intracavitarymalabsorption, it is worth considering congenital hypoplasia of the pancreas (hypoplasia). Symptoms occur from the first days or weeks of life. There is a liquid, abundant, quickened stool with an unpleasant odor and a greasy shine. Fat can even leak constantly from the anus.
Post celular malabsorption of the intestineis observed with exudative enteropathy. This is a syndrome in which plasma protein is lost through the mucous membrane. The cause of exudative enteropathy can be the presence of a congenital malformation of the lymphatic vessels of the intestine. Most often, the syndrome causes diseases of Whipple, Crohn, small bowel tumors, food allergies.
Exudative enteropathy sometimes occurs withoutobvious clinical manifestations. Symptoms such as diarrhea and steatorrhea may occur. Patients develop peripheral edema, localized on the face, lower back, perineum, extremities.
Enterocellular type of SMA with impaired absorptioncan be caused by a pathology such as glucose-galactose malabsorption. This is a hereditary disease in which the active transport of galactose and glucose in the mucosa of the small intestine is disturbed. The ailment from the first days of life is manifested by diarrhea. Fecal masses are allocated from 10 to 20 times per day. They are watery, reminiscent of urine. The child's body temperature rises, vomiting occurs. With the abolition of dairy nutrition, the symptoms go away. Poor tolerance of sweets and milk remains for life.
Another example of enterocellular CMA -impaired absorption of fructose. This is a rare genetic malabsorption. Symptoms occur after eating fruits and juices containing a large amount of fructose in their composition. These are apples, and oranges, and cherries, and cherries. That fructose, which is not absorbed by the body, causes flatulence, watery diarrhea, and colicky pain in the abdomen. In some cases, vomiting occurs. The severity of the symptoms depends on the amount of fructose that has got into the body.
The most common cause of enterocellularmalabsorption with violation of the membrane digestion is a disaccharidase insufficiency. With it, disaccharides are not completely cleaved. They are not absorbed when entering the distal parts of the intestine and are subjected to bacterial fermentation with the release of hydrogen. There are attacks of intestinal colic, bloating, diarrhea, decreased appetite, regurgitation, vomiting.
Enterocellular malabsorption of the intestine witha violation of absorption and digestion can be observed with celiac disease. This is a chronic hereditary disease in which the villi of the small intestine are damaged by certain food products. Celiac disease occurs in children several months after the introduction of gluten-containing foods into the diet. When the disease:
Diagnosis of malabsorption is not carried out. Specialists in identifying the symptoms of SMA prescribe to their patients the delivery of special tests and tests to confirm any suspected pathology that provoked a violation of absorption or digestion.
When conducting diagnostics, doctors are guided by the following algorithm developed by the World Gastroenterological Organization:
Further diagnosis of malabsorption syndromeincludes the implementation of studies with suspicion of celiac disease, the presence of lamblia, bacteria and parasites in the body. Important diagnostic information allows you to obtain an ultrasound examination of the internal organs of the abdominal cavity. Thanks to ultrasound, it is possible to assess the condition of the liver, pancreas, gall bladder, lymph nodes.
To exclude or confirm an autoimmunegastritis, celiac disease, Crohn's disease requires esophagogastroduodenoscopy with biopsy of the stomach and duodenum. To confirm the insufficiency of the exocrine function of the pancreas, feces, computer and magnetic resonance imaging, retrograde cholangiopancreatography for the visualization of ducts are performed. To learn about the presence or absence of ileal intestinal lesion, specialists prescribe ileocolonoscopy with a biopsy from the area under examination and the colon.
After diagnosing the cause of malabsorption, the doctor prescribes etiotropic treatment aimed at eliminating the detected disease. For example:
With severe diarrheal syndrome, whichcauses malabsorption, the treatment can be etiological, pathogenetic and symptomatic. Etiological and pathogenetic therapy can be the following means:
Symptomatic treatment includes taking probiotics, opiates, Loperamide, adsorbing agents (bismuth preparations, Diosmectite).
Engage in self-medicationSymptoms of SMA can not. It will not give positive results. In addition, malabsorption is a manifestation of serious and dangerous diseases. If there are signs of AGR, it is recommended that you consult a doctor. Only a specialist can name the true cause of the syndrome and prescribe an effective therapy to eliminate the diagnosed disease.